Check Existing Backup Infrastructure (VBR)
Check the hypervisor
Choose Backup infrastructure > Managed servers
Open the Properties of the host
Run through the wizard. If any of the settings are not correct, start again.
Check the Local Repository
Choose Backup Infrastructure > Backup repositories.
Open the properties of all the repositories that you see there and review the configuration.
If they point to incorrect drives, delete them and create a new repository.