Check Existing Backup Infrastructure (VBR)

Check the hypervisor

Choose Backup infrastructure > Managed servers 

Open the Properties of the host

Run through the wizard. If any of the settings are not correct, start again.

Check the Local Repository

Choose Backup Infrastructure > Backup repositories.

Open the properties of all the repositories that you see there and review the configuration.

If they point to incorrect drives, delete them and create a new repository.